Gut Health, Tryptophan, and Serotonin

Tryptophan is the sole precursor of the key neuroendocrine transmitter serotonin - which is involved in modulating the process of central neurotransmission and enteric physiological function. Due to its role in the biosynthesis of serotonin, it also directly participates in the synthesis of the pineal hormone - melatonin.

Melatonin does not have sedation properties, nor should be supplemented. Its primary role is in helping regulate circadian rhythm and synchronize our sleep-wake cycle with night and day in our environment.

The Microbiota and Tryptophan

The gut microbiota plays a key role in modulating tryptophan metabolism, directly affecting the balance between serotonin synthesis and tryptophan degradation. The gut microbiota modulates GBA function through an interplay between the immune systems, bacterial metabolites (including SCFAs such as butyrate), and changes in the tryptophan metabolism.

Host tryptophan metabolism is hence directly and indirectly modulated by the gut microbiota. Therefore, tryptophan metabolism represents a direct link between the intestinal microbiota and gut-brain axis (GBA) health and function.

Since many factors can influence the gut microbiota composition and metabolism, including diet, antibiotics and bacterial cultures intake via medicines and fermented foods and drinks, the manipulation of the gut microbiota, modulating tryptophan availability, may be a therapeutic option for GBA disorders, such as depression and IBS, as well as a tool for restoring overall health status in humans..

So what is the most convenient strategy to keep bugs in your gut happy and optimize serotonin production in your body? Scientific studies showed that regular consumption of fermented foods and drinks directly modulates tryptophan availability. Try our fermented micro-drinks to support your optimal levels of tryptophan and improve your overall quality of life :-D.